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KMID : 0379520210370020249
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한국독성학회지
2021 Volume.37 No. 2 p.249 ~ p.260
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β-caryophyllene improves sexual performance via modulation of crucial enzymes relevant to erectile dysfunction in rats
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Adefegha Stephen A.
Oboh Ganiyu
Olopade Elijah O.
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Abstract
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This study sought to investigate the effect of β-caryophyllene (BCP) on sexual performance, crucial enzymes linked to erectile function as well as lipid peroxidation in the penile tissue of paroxetine (PD)-induced rats. Animals were randomly divided into ten groups of five animals each: normal control (NC), BCP (10 mg/kg), BCP (20 mg/kg), sildenafil citrate (SD) (20 mg/kg), BCP?+?SD (20 mg/kg), PD (20 mg/kg), PD?+?BCP (10 mg/kg), PD?+?BCP (20 mg/kg), PD?+?SD (20 mg/kg) and PD?+?BCP (20 mg/kg)?+?SD (20 mg/kg). Oral administration of 20 mg/kg body weight of PD for the first 7 days was done while treatment with BCP and SD were performed between 8 and 14 days prior to euthanasia. The sexual performance study revealed that PD caused erectile dysfuction. Elevated activities of phosphodiesterase-5′ (PDE-5′), arginase, adenosine deaminase (ADA), acetylcholinesterase (AChE) and angiotensin-I converting enzyme (ACE) as well as lipid peroxidation level were observed in PD-induced rats when compared to the NC group. However, treatment with sildenafil and/ or β-Caryophyllene significantly reduced the activities of AChE, PDE-5′, arginase, ADA, and ACE in penile tissues of PD-induced rats. In addition, co-administration of β-caryophyllene and sildenafil citrate showed better modulatory effects. Thus, β-caryophyllene could represent a potential nutraceutical in the management of erectile dysfunction.
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KEYWORD
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β-caryophyllene, Sildenafil citrate, Paroxetine, Enzymes, Erectile dysfunction
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